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Key Documents

SRP3318

Sigma-Aldrich

C1 Inhibitor Peptide

≥95% (HPLC), lyophilized powder, human recombinant, expressed in CHO cells

同義詞:

C1inh, Plasma protease C1 inhibitor, Serpin G1

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

product name

C1 Inhibitor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

生物源

human

重組細胞

expressed in CHO cells

化驗

≥95% (HPLC)
≥95% (SDS-PAGE)

形狀

lyophilized

效力

≤2.6 nM IC50

分子量

52.8 kDa

包裝

pkg of 200 μg

雜質

endotoxin, tested

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... SERPING1(710)

一般說明

Plasma protease C1 inhibitor is a member of the serpin family of structurally related proteins. Recombinant Human C1 inhibitor is a highly glycosylated glycoprotein containing 478 amino acid residues (52.8kDa), corresponding to amino acids 23-500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex. Glycosylated C1 inhibitor migrates at an apparent molecular weight of approximately 80-90kDa by SDS PAGE analysis under reducing conditions.

生化/生理作用

Plasma protease C1 inhibitor is the primary regulator of the immune complement system. C1 inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1 inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1 inhibitor can be used to treat HAE and certain other conditions.

外觀

Lyophilized from 10mM Sodium Phosphate, pH 7.5.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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C1 inhibitor.
A E Davis et al.
Methods in enzymology, 223, 97-120 (1993-01-01)
C1-inhibitor deficiency and angioedema.
Carugati A
Molecular Immunology, 38(2-3), 161-173 (2001)
C1 Esterase Inhibitor (Human)
P & T : A Peer-Reviewed Journal for Formulary Management, 35, 2-3 (2010)
Sayani Mukherjee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(41), 7965-7979 (2020-09-06)
Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. We determined
In vivo biosynthesis of endogenous and of human C1 inhibitor in transgenic mice: tissue distribution and colocalization of their expression.
Vinci G
Journal of Immunology, 169(10), 5948-5954 (2002)

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