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Merck
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重要文件

SRP0371

Sigma-Aldrich

PKG1alpha active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

同義詞:

PRKG1, PRKGR1B, protein kinase, cGMP-dependent, type I

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About This Item

CAS號碼:
141588-27-4
分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

重組細胞

expressed in baculovirus infected Sf9 cells

化驗

≥70% (SDS-PAGE)

形狀

aqueous solution

分子量

80 kDa

包裝

pkg of 10 μg

儲存條件

avoid repeated freeze/thaw cycles

濃度

0.45 mg/mL

技術

activity assay: suitable
inhibition assay: suitable

NCBI登錄號

NM_001098512

UniProt登錄號

Q13976

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... PRKG1(5592)

一般說明

cGMP dependent Human PKG1alpha (GenBank Accession No. NM_001098512), full length with N-terminal His-tag, MW = 80 kDa, expressed in Baculovirus infected Sf9 cell expression system.

應用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
4008200519

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Alok K Sharma et al.
The Journal of biological chemistry, 283(47), 32860-32869 (2008-09-11)
Nitric oxide and nitrovasodilators induce vascular smooth muscle cell relaxation in part by cGMP-dependent protein kinase I (PKG-Ialpha)-mediated activation of myosin phosphatase (MLCP). Mechanistically it has been proposed that protein-protein interactions between the N-terminal leucine zipper (LZ) domain of PKG-Ialpha
D Pöhler et al.
FEBS letters, 374(3), 419-425 (1995-11-06)
Detailed studies of differences in distinct cGMP kinase isoforms are highly dependent on expression of large amounts of these enzyme isoforms that are not easily purified by conventional methods. Here cGMP-dependent protein kinases, the type I beta soluble form from
Mark J Ranek et al.
Nature communications, 11(1), 5237-5237 (2020-10-22)
Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing damaged proteins towards proteasome recycling. While enhancing

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