推薦產品
![Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) ≥95% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/235/466/8e0939d2-d5f9-46ee-ad12-f28fe40c308a/640/8e0939d2-d5f9-46ee-ad12-f28fe40c308a.png)
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
protect from light
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
-10 to -25°C
生化／生理作用
Serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) interaction blocker with antidepressant efficacy in vivo.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
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