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Merck
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重要文件

SML3638

Sigma-Aldrich

Ceftobiprole

≥95% (HPLC)

同義詞:

(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-ylidene)- 2-nitroso-1-oxoethyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)- 3-pyrrolidinyl]-3-pyrrolidinylidene]methyl]-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, BAL 9141, BAL 9141-000, Ro 63-9141

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About This Item

經驗公式(希爾表示法):
C20H22N8O6S2
CAS號碼:
分子量::
534.57
MDL號碼:
分類程式碼代碼:
51111800
分類程式碼代碼:
12352200
NACRES:
NA.25

品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (Acidified)

儲存溫度

-10 to -25°C

SMILES 字串

[s]1nc(nc1N)C(N=O)C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)\C=C4/CCN(C/4=O)[C@H]5CNCC5

InChI

1S/C20H22N8O6S2/c21-20-24-14(26-36-20)11(25-34)15(29)23-12-17(31)28-13(19(32)33)9(7-35-18(12)28)5-8-2-4-27(16(8)30)10-1-3-22-6-10/h5,10-12,18,22H,1-4,6-7H2,(H,23,29)(H,32,33)(H2,21,24,26)/b8-5+/t10-,11?,12-,18-/m1/s1

InChI 密鑰

XLHWFEHWWUCKOL-ADPMQJGOSA-N

生化/生理作用

Broad-spectrum cephalosporin active against MRSA
Ceftobiprole is a fifth generation broad spectrum cephalosporin that is active against many resistant bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole inhabits PBP1 (penicillin-binding protein 1), PBP2 and ß-lactam resistance determinant PBP2a.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Gunnar T R Hischebeth et al.
Diagnostic microbiology and infectious disease, 91(2), 175-178 (2018-02-18)
Antibiotic therapy is essential in foreign body associated infections. The treatment regime should aim at high tissue concentrations, high bioavailability, high biofilm penetration and good tolerance. We investigated whether the new cephalosporin ceftobiprole is active against clinical isolates from musculoskeletal
Impact of PBP4 Alterations on ?-Lactam Resistance and Ceftobiprole Non-Susceptibility Among Enterococcus faecalis Clinical Isolates
Lazzaro LM, Cassisi M, Stefani S, Campanile F
Frontiers in Cellular and Infection Microbiology, 11, 816657-816657 (2022)

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