SML3623

DSRM-3716

≥98% (HPLC)

• 同義詞: 5-Iodoisoquinoline, DSRM 3716, DSRM3716
• 經驗公式（希爾表示法）: C₉H₆IN
• CAS號碼: 58142-99-7
• 分子量：: 255.06
• MDL號碼: MFCD11226893
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , yellow to light brown
• 溶解度: DMSO: 2 mg/mL, clear (Warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: Ic1c2c(cncc2)ccc1
• InChI 密鑰: CUILFTFMBBGSFT-UHFFFAOYSA-N

描述

生化／生理作用

DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 µM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 µM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 µM DSRM-3716 against 25 µM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.

Potent and selective SARM1 NADase inhibitor that protects axons from degeneration induced by axotomy or mitochondrial dysfunction.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H302,H311,H315,H319,H412
• 防範說明: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable