SML3446

VT107

≥98% (HPLC)

• 同義詞: (S)-N-(l-(6-Aminopyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide, N-[(1S)-1-(6-Amino-2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide, VT 107
• 經驗公式（希爾表示法）: C₂₅H₂₀F₃N₃O
• CAS號碼: 2417718-63-7
• 分子量：: 435.44
• MDL號碼: MFCD34368522
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

描述

生化／生理作用

VT107 is a potent pan-TEAD auto-palmitoylation inhibitor (3 μM; using TEAD isotype-overexpressing HEK293T) that blocks TEAD-mediated gene transcription (IC50 = 4.93 nM) by preventing its association with YAP/TAZ. VT107 selectively inhibits the proliferation of mesothelioma cultures with NF2 mutation (NCI-H2051 IC50 = 20.4 nM), deletion (NCI-H2373 IC50 = 9.35 nM) or deficiency (NCI-H226 IC50 = 8.67 nM), but not those with wild-type NF2.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable