SML3430

Benvitimod

≥98% (HPLC)

• 同義詞: (E)-2-Isopropyl-5-styrylbenzene-1,3-diol, 3,5-Dihydroxy-4-isopropyl-trans-stilbene, 3,5-Dihydroxy-4-isopropylstilbene, GSK-2894512, Tapinarof, WBI 1001
• 經驗公式（希爾表示法）: C₁₇H₁₈O₂
• CAS號碼: 79338-84-4
• 分子量：: 254.32
• MDL號碼: MFCD13193203
• 分類程式碼代碼: 41121706
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , White to Very dark grey
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: CC(C1=C(C=C(C=C1O)/C=C/C2=CC=CC=C2)O)C
• InChI: 1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
• InChI 密鑰: ZISJNXNHJRQYJO-CMDGGOBGSA-N

描述

生化／生理作用

Aryl hydrocarbon receptor (AHR) immunomodulator that inhibits skin inflammation and enhances skin barrier function.

Benvitimod (Tapinarof) is an aryl hydrocarbon receptor (AHR) immunomodulator that inhibits skin inflammation and enhances skin barrier function. Benvitimod is a metabolite, similar to resveratrol, produced by bacterial symbionts of entomopathogenic nematodes. It induces downregulation of inflammatory cytokines such as IL-17A, IL-17F, IL-19, IL-22, IL-23, and IL-1. Benvitimod also induces the expression of skin barrier genes related to keratinocyte differentiation.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable