SML3365

MZ1

≥98% (HPLC)

• 同義詞: (2S,4R)-1-((2S)-2-tert-Butyl-17-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecane)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (2S,4R)-1-((S)-1-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-17,17-dimethyl-2,14-dioxo-6,9,12-trioxa-3,15-diazaoctadecanecarbonyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (4R)-N-[14-[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, MZ 1, MZ 1 (PROTAC)
• 經驗公式（希爾表示法）: C₄₉H₆₀ClN₉O₈S₂
• CAS號碼: 1797406-69-9
• 分子量：: 1002.64
• MDL號碼: MFCD30742945
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear (Warmed)
• 儲存溫度: -10 to -25°C
• SMILES 字串: O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C
• InChI 密鑰: PTAMRJLIOCHJMQ-PYNGZGNASA-N

描述

生化／生理作用

BRD4 degrader

MZ1 is a BRD4 degrader composed of pan-BET selective bromodomain inhibitor and the E3 ubiquitin ligase VHL ligand that induces preferential degradation of BRD4 over BRD2 and BRD3. MZ1exhibits antiproliferative effects in AML colorectal cancer cells lines.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable