SML3112

cis-22a

≥98% (HPLC)

• 同義詞: 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine, trifluoroacetate (1:2), cis-1-(4-(3-Methylphenyl)cyclohexyl)-4-((pyridin-4-yl)methyl)piperazine, trifluoroacetate (1:2)
• 經驗公式（希爾表示法）: C₂₂H₂₉N₃ · 2CF₃CO₂H
• CAS號碼: 1819366-84-1
• 分子量：: 563.53
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: H₂O: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

描述

生化／生理作用

cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2⁺ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable