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Merck
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SML3079

Sigma-Aldrich

Ponalrestat

≥98% (HPLC)

同義詞:

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid, ICI 128436, MK538

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About This Item

經驗公式（希爾表示法）:
C17H12BrFN2O3
CAS號碼:
72702-95-5
分子量：:
391.19
MDL號碼:
MFCD00204117
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

OC(CC(C1=CC=CC=C1C2=O)=NN2CC3=CC=C(C=C3F)Br)=O

InChI

1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)

InChI 密鑰

LKBFFDOJUKLQNY-UHFFFAOYSA-N

生化／生理作用

Ponalrestat is an orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2) that blocks the conversion of glucose to sorbitol. Ponalrestat promotes root elongation through the inhibition of the flavin monooxygenase YUCCA in Arabidopsis.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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Guang Wang et al.
Chemical research in toxicology, 33(8), 2164-2171 (2020-07-09)
Bile acids (BAs) play essential physiological roles not only by facilitating the absorption and transport of nutrients but also by acting as a complex molecular signaling system. Reduced levels of BAs have been observed in obesity and other metabolic disorders.
Ajmer Singh Grewal et al.
Mini reviews in medicinal chemistry, 16(2), 120-162 (2015-09-10)
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose reductase (AR) is an enzyme of aldoketo reductase super-family

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