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About This Item
經驗公式（希爾表示法）:
C15H11FN2
CAS號碼:
分子量：:
238.26
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
InChI
1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
InChI 密鑰
YBSDQTBCNYWBMX-ONEGZZNKSA-N
應用
680C91可用于：
- 作为色氨酸 2,3 双加氧酶（TDO）抑制剂，研究其对长鳍近海鱿鱼胚胎色素沉积的影响
- 作为 TDO 抑制剂，研究其在异种移植瘤实验中对食管鳞状细胞癌的影响
- 作为色氨酸 2,3 双加氧酶 2 （TDO2）抑制剂，研究其对人胚胎肾细胞毒性片段形成的影响
生化／生理作用
680C91 对单胺氧化酶 A 和 B、吲哚胺 2,3-双加氧酶和 5-羟色胺（5-HT）摄取以及 5-HT1A、1D、2A 和 2C 受体无抑制作用。
680C91 是色氨酸 2,3-双加氧酶（TDO）的有效抑制剂，该酶可指导色氨酸转化为犬尿氨酸。最近，犬尿氨酸被鉴定为芳烃受体（AHR）的内源性配体。TDO 在神经胶质瘤细胞中高表达，并有助于 AHR 介导的神经胶质瘤细胞存活并抑制抗肿瘤免疫反应。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines.
Sara Paccosi et al.
Journal of cancer research and clinical oncology, 146(12), 3155-3163 (2020-08-11)
Indoleamine 2,3-dioxygenase-1 (IDO1) and more recently, tryptophan 2,3-dioxygenase (TDO), are tryptophan-catabolizing enzymes with immunoregulatory properties in cancer. IDO1 is more expressed than TDO in many tumours including melanomas; however, IDO inhibitors did not give expected results in clinical trials, highlighting
Karthyayani Rajamani et al.
Neuropharmacology, 117, 434-446 (2017-02-23)
Spinocerebellar ataxia type 3 or Machado-Joseph disease (SCA3/MJD) is characterized by the repetition of a CAG codon in the ataxin-3 gene (ATXN3), which leads to the formation of an elongated mutant ATXN3 protein that can neither be denatured nor undergo
Carlo Breda et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(19), 5435-5440 (2016-04-27)
Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has highlighted the therapeutic potential of inhibiting two critical regulatory enzymes in this pathway-kynurenine-3-monooxygenase (KMO) and tryptophan-2,3-dioxygenase
Tryptophan 2, 3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3 beta IL-8 signaling pathway
Zhao Y, et al.
Acta pharmaceutica Sinica. B (2021)
Vasco Rodrigues et al.
Frontiers in cellular and infection microbiology, 9, 338-338 (2019-10-23)
Disease manifestation after infection with cutaneous Leishmania species is the result of a complex interplay of diverse factors, including the immune status of the host, the infecting parasite species, or the parasite load at the lesion site. Understanding how these
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