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SML2975

Sigma-Aldrich

Dabcyl-KTSAVLQSGFRKME-Edans trifluoroacetate

≥95% (HPLC), powder, FRET substrate of SARS-CoV Mpro

同義詞:

DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS trifluoroacetate, N2-[4-[[4-(Dimethylamino)phenyl]azo]benzoyl]-L-lysyl-L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-L-lysyl-L-methionyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-α-glutamine trifluoroacetate

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About This Item

經驗公式(希爾表示法):
C95H141N25O24S2 · xC2HF3O2
CAS號碼:
分子量::
2081.42 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77

產品名稱

Dabcyl-KTSAVLQSGFRKME-Edans trifluoroacetate, ≥95% (HPLC)

品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

light brown to dark red

儲存溫度

−20°C

生化/生理作用

Dabcyl-KTSAVLQSGFRKME-Edans is a fluorescence resonance energy transfer (FRET) substrate for SARS-CoV main protease Mpro (also called 3CLpro) (538 nm with excitation at 355 nm). Dabcyl-KTSAVLQSGFRKME-Edans is suitable to measure protease activity of COVID-19 virus Mpro, SARS-CoV Mpro, and other viruses.
FRET substrate suitable to measure protease activity of COVID-19 virus Mpro, SARS-CoV Mpro, and some other viruses

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Linlin Zhang et al.
Journal of medicinal chemistry, 63(9), 4562-4578 (2020-02-12)
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral polyprotein

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