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Merck
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SML2739

Sigma-Aldrich

SM1-71-R

≥98% (HPLC)

同義詞:

N-[2-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]propanamide

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About This Item

經驗公式(希爾表示法):
C24H28ClN7O
CAS號碼:
分子量::
465.98
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

生化/生理作用

SM1-71-R, a reversible analog of multi-targeted kinase covalent inhibitor SM1-71, is a cell penetrant and potent multi-targeted kinase inhibitor. SM1-71-R can be used as a washout control to distinguish between covalent and non-covalent inhibition.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Li Tan et al.
Bioorganic & medicinal chemistry, 25(3), 838-846 (2016-12-25)
TAK1 (transforming growth factor-β-activated kinase 1) is an essential intracellular mediator of cytokine and growth factor signaling and a potential therapeutic target for the treatment of immune diseases and cancer. Herein we report development of a series of 2,4-disubstituted pyrimidine
Suman Rao et al.
Cell chemical biology, 26(6), 818-829 (2019-04-16)
Covalent kinase inhibitors, which typically target cysteine residues, represent an important class of clinically relevant compounds. Approximately 215 kinases are known to have potentially targetable cysteines distributed across 18 spatially distinct locations proximal to the ATP-binding pocket. However, only 40

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