SML1350

EPPTB

≥95% (HPLC)

• 同義詞: N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide, RO5212773
• 經驗公式（希爾表示法）: C₂₀H₂₁F₃N₂O₂
• CAS號碼: 1110781-88-8
• 分子量：: 378.39
• MDL號碼: MFCD21605509
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825806
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CCOC1=CC=CC(NC(C2=CC(C(F)(F)F)=C(N3CCCC3)C=C2)=O)=C1
• InChI: 1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26)
• InChI 密鑰: KLFVWQCQUXXLOU-UHFFFAOYSA-N

描述

生化／生理作用

EPPTB is a selective antagonist of the trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor (GPCR) activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β)-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). TAAR1 is considered a promising target for the treatment of neuropsychiatric disorders, however study of TAAR1 has hampered by the fact that selective ligands have not been available. EPPTB is the first potent and selective TAAR1 antagonist with an IC₅₀ of 28 nM at mouse TAAR1. EPPTB is less selective for rat and human with IC₅₀ values of 4539 and 7487 nM, respectively.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable