推薦產品
化驗
≥95% (HPLC)
形狀
oil
儲存條件
desiccated
under inert gas
顏色
colorless to yellow
儲存溫度
−20°C
SMILES 字串
CCCCCCCCOC(C(CCC(O)=O)=O)=O
InChI
1S/C13H22O5/c1-2-3-4-5-6-7-10-18-13(17)11(14)8-9-12(15)16/h2-10H2,1H3,(H,15,16)
InChI 密鑰
QNFIHKFBQFJVKV-UHFFFAOYSA-N
應用
辛基-α-KG研究已用于研究其在细胞活力及补充脑胶质母细胞瘤细胞α-KG水平方面的作用。
生化／生理作用
α-酮戊二酸的膜可渗透前体，其可恢复癌细胞中α-KG依赖性双加氧酶的活性。
辛基α-KG（辛基-2KG）是α-酮戊二酸（α-KG或2KG）的一种膜渗透性前体形式，由于NADP+-依赖的异柠檬酸脱氢酶基因IDH1和IDH2发生突变，因此在肿瘤细胞中经常可以观察到-KG的下调并伴随D-2-羟基戊二酸（D-2HG）的上调，从而导致多种α-KG依赖性双加氧酶的活性降低。通过辛基-α-KG处理（1-5 mM）进行的细胞α-KG的递送可在辛基-2-HG（1-50 mM）处理或IDH1（R132H）突变体表达后恢复细胞脱甲基酶的活性。 在由于琥珀酸脱氢酶（SDH）和/或富马酸盐水合酶（FH）缺乏，而导致三羧酸（TCA）循环失调的细胞中，辛基-α-KG还可以有效地重新激活α-KG依赖的双加氧酶脯氨酰羟化酶（PHD）活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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