推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
yellow to orange
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
InChI 密鑰
WZBDRAAGHRCRKM-UHFFFAOYSA-N
生化／生理作用
Myc inhibitor that disrupts the Myc-Max heterodimer
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Seung H Choi et al.
ACS chemical biology, 12(11), 2715-2719 (2017-10-05)
Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human cancers, there is no Myc targeted therapy yet. Here, we report sAJM589, a novel small molecule
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