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Key Documents

F3680

Sigma-Aldrich

10058-F4

≥98% (HPLC), solid

同義詞:

5-[(4-乙基苯基)亚甲基]-2-硫代-4-噻唑烷酮

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About This Item

經驗公式(希爾表示法):
C12H11NOS2
CAS號碼:
分子量::
249.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

顏色

yellow

溶解度

DMSO: >10 mg/mL
H2O: <2 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCc1ccc(cc1)\C=C2\SC(=S)NC2=O

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChI 密鑰

SVXDHPADAXBMFB-JXMROGBWSA-N

應用

10058-F4 已用于:
  • 作为c-Myc抑制剂用于处理基质细胞
  • 作为c-Myc抑制剂用于确定c-Myc抑制对心脏祖细胞(CPC)生长的影响
  • 作为 c-Myc 抑制剂用于培养T细胞
  • 处理C4-2细胞以考察MST1启动子荧光素酶报告基因构建体(reporter construct)的活性

生化/生理作用

10058-F4是一种c-Myc抑制剂,可诱导细胞周期组滞和细胞凋亡。10058-F4是一种细胞渗透性噻唑烷酮,它能够特异性地抑制c-Myc-Max相互作用并阻止c-Myc靶基因表达的反式激活。10058-F4在体外体内均以c-Myc依赖性方式抑制肿瘤细胞生长(64 μM,使用c-Myc转染的Rat1a成纤维细胞)。

特點和優勢

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential
Bellio MA, et al.
Scientific reports, 7(1), 9702-9702 (2017)
cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response
Madapura HS, et al.
Cell Cycle, 15(9), 1267-1275 (2016)
Bethany C Prudner et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5122-5134 (2019-05-23)
The response to acute and long-term arginine starvation results in a conditional adaptive metabolic reprogramming that can be harnessed for therapeutic opportunities in ASS1-negative tumors. Here, we investigate the underlying biology of priming ASS1- tumors with arginine deiminase (ADI-PEG20) before
Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression
Kuser-Abali G, et al.
Epigenetics, 9(4), 634-643 (2014)
Camilla U Persson et al.
Scientific reports, 7(1), 10274-10274 (2017-09-02)
Cultured cancer cells serve as important models for preclinical testing of anti-cancer compounds. However, the optimal conditions for retaining original tumor features during in vitro culturing of cancer cells have not been investigated in detail. Here we show that serum-free

文章

Sigma-Aldrich presents an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

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