推薦產品
化驗
>97% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
H2O: 2 mg/mL, clear (warmed)
儲存溫度
2-8°C
生化／生理作用
BOP (N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt) is a potent and selective dual inhibitor of integrins alpha-4 beta-1 (α4β1) and alpha-9 beta-1 (α9β1) with Kd values in the picomolar range. BOP has been shown to preferentially mobilize hematopoietic stem cells (HSCs) and progenitors and to act synergistically with AMD3100.
Dual α9β1/α4β1 integrin inhibitor
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
R Blake Pepinsky et al.
Biochemistry, 41(22), 7125-7141 (2002-05-30)
Integrins alpha9beta1 and alpha4beta1 form a distinct structural class, but while alpha4beta1 has been subjected to extensive study, alpha9beta1 remains poorly characterized. We have used the small molecule N-(benzenesulfonyl)-(L)-prolyl-(L)-O-(1-pyrrolidinylcarbonyl)tyrosine (3) to investigate the biochemical properties of alpha9beta1 and directly compare
Benjamin Cao et al.
Nature communications, 7, 11007-11007 (2016-03-16)
The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting α9β1/α4β1 integrins with a single dose of
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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