SML1929

Equisetin

(Fusarium equiseti), ≥97% (HPLC)

• 同義詞: (3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
• 經驗公式（希爾表示法）: C₂₂H₃₁NO₄
• CAS號碼: 57749-43-6
• 分子量：: 373.49
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 200
• 生物源: (Fusarium equiseti)
• 化驗: ≥97% (HPLC)
• 形狀: powder
• 溶解度: DMSO: soluble 1 mg/mL; chloroform: soluble 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: C[C@H]1C[C@]2([H])[C@@]([C@](C)(/C(O)=C3C([C@H](CO)N(C)C/3=O)=O)[C@H](/C=C/C)C=C2)([H])CC1
• InChI: 1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,27H,7,10-12H2,1-4H3/b6-5+/t13-,14-,15-,16-,17+,22-/m1/s1
• InChI 密鑰: SLOQQJFOWFUUMP-KNQICWOTSA-N

描述

生化／生理作用

Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC₅₀ values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable