SML1863

NSC57969

≥98% (HPLC)

• 同義詞: 7-(1-Piperidinylmethyl)-8-quinolinol, 7-(Piperidinomethyl)-8-quinolinol, 8-Hydroxy-7-(piperidinomethyl)quinoline
• 經驗公式（希爾表示法）: C₁₅H₁₈N₂O
• CAS號碼: 6632-09-3
• 分子量：: 242.32
• MDL號碼: MFCD00469245
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
• InChI: 1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
• InChI 密鑰: WXMFPLZGDXLEMN-UHFFFAOYSA-N

描述

生化／生理作用

MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines

NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable