233165

Clioquinol

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

• 同義詞: Clioquinol, 5-Chloro-7-iodo-8-hydroxyquinoline
• 經驗公式（希爾表示法）: C₉H₅ClINO
• CAS號碼: 130-26-7
• 分子量：: 305.50
• MDL號碼: MFCD00006787
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 溶解度: ethanol: 1 mg/mL; methanol: 1.5 mg/mL; DMSO: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• InChI 密鑰: QCDFBFJGMNKBDO-UHFFFAOYSA-N

描述

一般說明

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that reduces the build-up of these deposits. Exhibits greater affinity for Cu²⁺ and Zn²⁺ than for Ca²⁺ and Mg²⁺. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

生化／生理作用

Cell permeable: no

Primary Target
Metal ion chelator

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重構

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Melov, S. 2002. Trends Neurosci.25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.
Helmuth, L., et al. 2000. Science290, 1273.
Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H317,H319
• 防範說明: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3