推薦產品
生化／生理作用
BCI-121 是一种底物竞争性 SMYD3 抑制剂，可降低核组蛋白 H3 lys4 二甲基化和三甲基化的级别（通过HT29 细胞中 50%/H3K4me2 和 40%H3K4me3；48小时内100μM BCI-121实现），下调已知的 SMYD3 靶基因转录，并选择性影响 SMYD3 依赖的癌症培养物增殖（46%/HT29 和 54%/HCT116 增殖减少；72小时内的100μM BCI-121），对低表达 SMYD3 的癌细胞几乎没有抗增殖作用。BCI-121 通过直接亲和作用靶向 SMYD3（kon 357.7/M/s；k off 4.23 × 10 -3 /s；K D = K off/ K on = 11.8μM），并与组蛋白结合 SMYD3（% 抑制率/[组蛋白H4 肽]:[BCI-121] 比值 = 36.5%/1：1 和 51.0%/1：2.5）有效竞争。
BCI121能够减少MDA-MB-231细胞的间充质特征。它还可以降低它们体外和体内的入侵能力。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
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The coordinated expression of myogenic regulatory factors, including MyoD and myogenin, orchestrates the steps of skeletal muscle development, from myoblast proliferation and cell-cycle exit, to myoblast fusion and myotubes maturation. Yet, it remains unclear how key transcription factors and epigenetic
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SMYD3 is a histone lysine methyltransferase that plays an important role in transcriptional activation as a member of an RNA polymerase complex, and its oncogenic role has been described in different cancer types. We studied the expression and activity of
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