SML1790

他立喹达

≥98% (HPLC)

• 同義詞: N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide, XR 9576, XR9576
• 經驗公式（希爾表示法）: C₃₈H₃₈N₄O₆
• CAS號碼: 206873-63-4
• 分子量：: 646.73
• MDL號碼: MFCD09837824
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826066
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to light brown
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CC(C=CC=C3)=C3N=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5
• InChI: 1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43)
• InChI 密鑰: LGGHDPFKSSRQNS-UHFFFAOYSA-N

描述

生化／生理作用

Specific inhibitor of MDR-1 (P-gp)

Tariquidar is a non-competitive inhibitor. It is used as a potential agent for checking the role of P-glycoprotein inhibition in cancer. Tariquidar also has an ability to enhance drug exposure in drug-resistant cancers.

Tariquidar is a potent MDR1 (P-gp, P-glycoprotein) inhibitor. Tariquidar reverses multidrug resistance (MDR) by inhibiting MDR1-mediated drug efflux.

安全資訊

• 危險聲明: H413
• 防範說明: P273 - P501
• 危險分類: Aquatic Chronic 4
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable