SML1701

BX430

≥98% (HPLC)

• 同義詞: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N′-(3-pyridinyl)urea
• 經驗公式（希爾表示法）: C₁₅H₁₅Br₂N₃O
• CAS號碼: 688309-70-8
• 分子量：: 413.11
• MDL號碼: MFCD02678819
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826026
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O
• InChI: 1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
• InChI 密鑰: JFNKIJKRXKPQCC-UHFFFAOYSA-N

描述

生化／生理作用

BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels.

BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNS, and have been studied as a therapeutic target for neuropathic pain and inflammation, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. BX430 is highly selective for human P2X4, with minimal activity towards other P2X subtypes, including P2X1–P2X3, P2X5, and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 receptors. BX430 has an IC₅₀ value of 540 nM.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable