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About This Item
經驗公式（希爾表示法）:
C18H16Cl2N4
CAS號碼:
分子量：:
359.25
MDL號碼:
分類程式碼代碼:
12171501
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to light brown
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1
InChI
1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
InChI 密鑰
ABGOSOMRWSYAOB-UHFFFAOYSA-N
生化／生理作用
A-196是SUV420H1和SUV420H2的一种有效且选择性的化学抑制剂，可抑制多种细胞系中H4K20me的二甲基和三甲基化。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的 A-196 探针摘要 。
SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
SGC2043是活性探针A-196的阴性对照。若需向SGC索要阴性对照样品，请 点击这里。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
特點和優勢
A-196是一种表观遗传化学探针，通过与Structural Genomics Consortium（SGC）合作获得。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Wendan Ren et al.
Nature communications, 12(1), 2490-2490 (2021-05-05)
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how these two chromatin modifications crosstalk. Here, we report that DNA
Alena Svobodová Kovaříková et al.
Cells, 9(2) (2020-02-09)
The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA polymerases I and
Lenka Stixová et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 27(1-2), 41-55 (2019-01-06)
Repair of ribosomal DNA (rDNA) is a very important nuclear process due to the most active transcription of ribosomal genes. Proper repair of rDNA is required for physiological biogenesis of ribosomes. Here, we analyzed the epigenetics of the DNA damage
Virginia López et al.
Frontiers in cell and developmental biology, 9, 671838-671838 (2021-08-28)
Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in adulthood. Epigenetic mechanisms are known to play a key role in GBM although the involvement of histone methyltransferase KMT5B and its mark H4K20me2 has remained largely
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