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Merck
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Key Documents

SML1495

Sigma-Aldrich

舒洛芬(Suprofen)

≥98% (HPLC)

同義詞:

(±)-Suprofen, 2-[4-(Thiophene-2-carbonyl)phenyl]propanoic acid, NSC 303611, p-(2-Thenoyl)hydratropic acid, α-Methyl-p-(2-thenoyl)phenylacetic acid

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About This Item

經驗公式(希爾表示法):
C14H12O3S
CAS號碼:
分子量::
260.31
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

room temp

SMILES 字串

CC(C(O)=O)c1ccc(cc1)C(=O)c2cccs2

InChI

1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

InChI 密鑰

MDKGKXOCJGEUJW-UHFFFAOYSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

應用

Suprofen has been used to evaluate the combination of trifluoroacetic acid and isopropylamine (IPA) in supercritical fluid chromatography. It has also been used to evaluate immobilized chiral polysaccharide-based stationary phases in supercritical fluid chromatography.

生化/生理作用

Suprofen is a nonsteroidal anti-inflammatory drug that inhibits COX-1/2. Suprofen exhibits a potent anti-inflammatory, analgesic and antipyretic activities.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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A S Nies
Agents and actions. Supplements, 24, 95-106 (1988-01-01)
All nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase, and consequently renal functions dependent upon prostaglandin synthesis can be affected. Fortunately, renal function in normal individuals is relatively independent of the PG system, and thus the NSAIDs don't usually produce any renal
Pharmaceutical-enantiomers resolution using immobilized polysaccharide-based chiral stationary phases in supercritical fluid chromatography
De Klerck
Journal of Chromatography A (2014)
C J Niemegeers et al.
Arzneimittel-Forschung, 25(10), 1505-1509 (1975-10-01)
A new standardized acetic acid-induced writhing test in rats is described in detail and its methodology is discussed briefly. The described method has proved to be useful for evaluating the anti-writhing activity of narcotic analgesics, non-narcotic anti-inflammatory compounds and narcotic-antagonists
R J Capetola et al.
The Journal of pharmacology and experimental therapeutics, 214(1), 16-23 (1980-07-01)
The antinociceptive properties of suprofen [alpha-methyl-4-(thienylcarbonyl)benzene acetic acid] are described in a pathologically induced hyperalgesic model, the rat adjuvant arthritis flexion test. By using this assay, suprofen was characterized as an orally effective, non-narcotic analgesic with a rapid onset and
Malin Darnell et al.
Chemical research in toxicology, 28(5), 886-896 (2015-03-25)
Xenobiotic carboxylic acids may be metabolized to oxidative metabolites, acyl glucuronides, and/or S-acyl-CoA thioesters (CoA conjugates) in vitro, e.g., in hepatocytes, and in vivo. These metabolites can potentially be reactive species and bind covalently to tissue proteins and are generally

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