SML1377

R-7050

≥95% (HPLC)

• 同義詞: 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline, 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
• 經驗公式（希爾表示法）: C₁₆H₈ClF₃N₄S
• CAS號碼: 303997-35-5
• 分子量：: 380.77
• MDL號碼: MFCD00140737
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329825827
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear (warmed)
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• SMILES 字串: ClC1=CC=C(N=C(SC2=CC=CC=C2)C3=NN=C(C(F)(F)F)N34)C4=C1
• InChI: 1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
• InChI 密鑰: SUUMKHOVGVYGOP-UHFFFAOYSA-N

描述

生化／生理作用

R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. R-7050 was found to reduce neurovascular injury in a mouse model of hemorrhagic stroke.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable