SML1337

NQ301

≥98% (HPLC)

• 同義詞: 2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione, Compound 211, NQ 301
• 經驗公式（希爾表示法）: C₂₃H₁₉N₃O · HBr
• CAS號碼: 130089-98-4
• 分子量：: 434.33
• MDL號碼: MFCD00559986
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825795
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , faint red to dark red
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
• InChI: 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
• InChI 密鑰: LSQZKIQSQHZVQS-UHFFFAOYSA-N

描述

生化／生理作用

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H400
• 防範說明: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable