SML1331

MLS1547

≥98% (HPLC)

• 同義詞: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol, MLS000051547
• 經驗公式（希爾表示法）: C₁₉H₁₉ClN₄O
• CAS號碼: 315698-36-3
• 分子量：: 354.83
• MDL號碼: MFCD02330713
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825789
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: OC1=C(CN2CCN(C3=NC=CC=C3)CC2)C=C(Cl)C4=CC=CN=C41
• InChI: 1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
• InChI 密鑰: OPEJNANYABTIGC-UHFFFAOYSA-N

描述

生化／生理作用

MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. MLS-1547 is the first D2 receptor agonist with close to full efficacy for G protein signaling (EC₅₀ = 370 nM), but no ability to recruit β-arrestin.

MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable