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Key Documents

SML1083

Sigma-Aldrich

利尿酸

≥97% (HPLC)

同義詞:

2-[2,3-二氯-4-(2-亚甲基-1-氧丁基)苯氧基] 乙酸, ECA, [2,3-二氯-4-(2-乙基丙烯酰基)苯氧基] 乙酸, 依他尼酸, (2,3-二氯-4-[2-亚甲基丁酰]苯氧基)乙酸

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About This Item

經驗公式(希爾表示法):
C13H12Cl2O4
CAS號碼:
分子量::
303.14
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥97% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI 密鑰

AVOLMBLBETYQHX-UHFFFAOYSA-N

基因資訊

human ... SLC12A1(6557)

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生化/生理作用

依他尼酸可增加苯丁酸氮芥对大鼠和人肿瘤细胞系的细胞毒性。
依他尼酸是非磺胺类环状利尿剂,用于治疗高血压和充血性心力衰竭等疾病引起的水肿。依他尼酸可阻断钠-钾-氯离子共同转运。此外,依他尼酸可强效抑制谷胱甘肽 S-转移酶家族成员。研究显示,依他尼酸可有效抑制包括肺癌和胰腺癌在内的癌细胞的 Tgase-2(转谷氨酰胺酶-2)依赖性转移。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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E Röth et al.
Experimental and clinical cardiology, 16(3), 92-96 (2011-11-09)
Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study was
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.
Ploemen J H, et al.
Biochemical Pharmacology, 40(7), 1631-1635 (1990)
Piriyaporn Thiendedsakul et al.
Veterinary world, 15(1), 46-54 (2022-04-05)
The crocodile is a model for studying relevant sources of environmental contamination. They were determined an appropriate biomonitoring species for various toxins. The cytosolic and microsomal fraction of crocodiles plays a role in detoxifying xenobiotics. Cytochrome P450 1A2 (CYP1A2) metabolizes
Hyun Jung Byun et al.
Biomolecules & therapeutics, 21(5), 338-342 (2013-11-19)
Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migration. Recently, we
Raymond P Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(16), 7479-7484 (2010-04-07)
Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been implicated, the molecular mechanism underlying this selectivity is unclear. In other cell types

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