SML1064

IMM-01

≥98% (HPLC)

• 同義詞: 2-[(2,4-Dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-hydrazinecarbothioamide, Intramimic-01, N1-(tert-Butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide
• 經驗公式（希爾表示法）: C₁₂H₁₇N₃O₂S
• CAS號碼: 218795-74-5
• 分子量：: 267.35
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to light brown
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C12H17N3O2S/c1-12(2,3)14-11(18)15-13-7-8-4-5-9(16)6-10(8)17/h4-7,16-17H,1-3H3,(H2,14,15,18)/b13-7+
• InChI 密鑰: LTFUAYRGVLQXKC-NTUHNPAUSA-N

描述

應用

IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs).

生化／生理作用

IMM-01 binds and activates formin thereby leading to autoinhinition.

IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable