SML1050

DC260126

≥98% (HPLC)

• 同義詞: N-(4-Butylphenyl)-4-fluoro-benzenesulfonamide
• 經驗公式（希爾表示法）: C₁₆H₁₈FNO₂S
• CAS號碼: 346692-04-4
• 分子量：: 307.38
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: Fc1ccc(cc1)[S](=O)(=O)Nc2ccc(cc2)CCCC
• InChI: 1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
• InChI 密鑰: CNGHPXKWPGIDSK-UHFFFAOYSA-N

描述

生化／生理作用

DC260126 is a FFA1 (GPR40) selective antagonist.

DC260126 is a FFA1 (GPR40) selective antagonist. In FFA1-expressing CHO cells, DC260126 blocks linoleic acid-induced Ca²⁺ elevation and ERK phosphorylation (IC₅₀ = 6028 μM), as well as palmitic acid potentiated glucose-stimulated insulin secretion. The compound DC260126 blocks MIN6 β cells from palmitic acid-induced ER stress and apoptosis.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable