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Key Documents

SML1018

Sigma-Aldrich

Cyclosporin A

≥95% (HPLC), DMSO solution, calcineurin inhibitor

同義詞:

CsA, 环孢霉素

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About This Item

經驗公式(希爾表示法):
C62H111N11O12
CAS號碼:
分子量::
1202.61
EC號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

环孢素A,即用型溶液, 1 mg/mL in DMSO

形狀

DMSO solution

品質等級

儲存條件

protect from light

濃度

1 mg/mL in DMSO

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+

InChI 密鑰

PMATZTZNYRCHOR-IMVLJIQESA-N

應用

环孢素A已用于研究其对3D近端肾小管灌注模型的毒性作用。

生化/生理作用

环孢素A(cyclosporin A)通常在移植术后给药,用于抗排斥反应。在对器官移植起效之外,环孢素A(CyA)也会带来肾毒性副作用。
环孢素A(cyclosporin A, CsA)是由多孔木霉(Tolypocladium inflatum)真菌合成的非极性环状多肽。它是一种强效的免疫抑制剂,主要作用于T淋巴细胞,已证明可在mRNA转录水平抑制多种核蛋白的T细胞活化作用。 它可与胞内受体亲环素形成复合物,复合物可结合一种钙离子/钙调依赖性蛋白磷酸酶——钙调神经磷酸酶(calcineurin),抑制其酶活性。 CsA可抑制培养肝细胞中丙型肝炎病毒基因组的复制。 > 10 nM浓度的CsA可保护肝细胞免遭鬼笔环肽破坏。 CsA可通过抑制钙调神经磷酸酶抑制T细胞活化生产 IL2
有大量引用本品的文献报道,包括对于其分析特性的全面综述。

其他說明

光敏感

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F - closed cup

閃點(°C)

87 °C - closed cup


分析證明 (COA)

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