C-093

环孢菌素A 溶液

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₆₂H₁₁₁N₁₁O₁₂
• CAS號碼: 59865-13-3
• 分子量：: 1202.61
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 1.0 mg/mL in acetonitrile
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing
• 形式: single component solution
• 儲存溫度: −70°C
• SMILES 字串: O=C(N(C)[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N(C)[C@H](C(N[C@@H](C)C(N[C@H](C)C(N(C)[C@@H](CC(C)C)C(N(C)[C@@H](CC(C)C)C(N([C@H](C(C)C)C(N(C)[C@@H]([C@@H]([C@H](C)C/C=C/C)O)C1=O)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)CN(C)C([C@@H](N1)CC)=O
• InChI: 1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50?,51+,52-/m1/s1
• InChI 密鑰: PMATZTZNYRCHOR-VPYFBNRVSA-N

描述

一般說明

免疫抑制剂和窄治疗指数的经认证加标溶液^®，用于预防器官移植中的排斥反应。这种经过认证的校准材料适用于临床和诊断测试（例如治疗药物监测分析）中的关键定量应用，以确保患者保持在药物窄治疗范围内。  Snap-N-Spike^®格式允许实验室消除诸如环孢菌素A之类的有害物质的称重操作，从而显著减少与处理急性毒性粉末有关的职业暴露危害，并提供在使用前将其加标到其选择的基质中的能力。

應用

• Novel IgE crosslinking-induced luciferase expression method using human-rat chimeric IgE receptor-carrying mast cells: This study leverages Cyclosporin A′s immunosuppressive properties to explore new methodologies for investigating allergic responses. By utilizing Cyclosporin A to modulate immune cell activity, researchers have developed an innovative in vitro assay that significantly enhances our understanding of immune mechanisms, demonstrating Cyclosporin A′s pivotal role in immunological research and its application in developing more effective allergy treatments (Akiyama H et al., 2024).


• Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics: This review discusses the critical role of Cyclosporin A in the development of nanocarrier systems for targeted drug delivery, particularly for ocular applications. Cyclosporin A′s effectiveness in preventing transplant rejection and its properties as a calcineurin inhibitor make it an excellent candidate for incorporation into advanced drug delivery systems, enhancing therapeutic efficacy and reducing systemic side effects (Datta D et al., 2024).


• A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: Demonstrating Cyclosporin A′s utility in enhancing the efficacy of controlled-release drug systems, this study details the use of Cyclosporin A with a novel xanthan gum-based platform. This research emphasizes Cyclosporin A′s role in the pharmaceutical industry, particularly in improving drug delivery mechanisms that can be crucial for treating chronic conditions (Signorini S et al., 2024).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H302 + H312 + H332,H319,H350
• 防範說明: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 35.6 °F - closed cup
• 閃點（°C）: 2 °C - closed cup