SML0996

Ospemifene

≥98% (HPLC)

• 同義詞: (deaminohydroxy)toremifene, 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol, FC-1271a
• 經驗公式（希爾表示法）: C₂₄H₂₃ClO₂
• CAS號碼: 128607-22-7
• 分子量：: 378.89
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
• InChI 密鑰: LUMKNAVTFCDUIE-VHXPQNKSSA-N

描述

生化／生理作用

Ospemifene is a selective estrogen receptor modulator (SERM), a metabolite of toremifene, with a unique estrogen agonist/antagonist tissue profile. Ospemifene was recently approved in the US for the treatment of dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is being investigated for the treatment and prevention of osteoporosis and breast cancer. Ospemifene binds ERα and ERβ with approximately equal affinities with IC₅₀ values for estrogen receptor (ER) α and β of 0.8 μM and 1.7 μM, respectively. Ospemifene has estrogen-like effects on the vaginal epithelium and bone, antiproliferative effects in breast, and a neutral endometrial profile.

安全資訊

• 象形圖: GHS09
• 訊號詞: Warning
• 危險聲明: H410
• 防範說明: P273 - P391 - P501
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable