推薦產品
產品名稱
GI254023X, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 15 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
ON(C=O)[C@@H](C)[C@@H](CCCC1=CC=CC=C1)C(N[C@@H](C(C)(C)C)C(NC)=O)=O
InChI
1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1
InChI 密鑰
GHVMTHKJUAOZJP-CGTJXYLNSA-N
應用
GI254023X 已被用于抑制 ADAM10（ADAM 金属肽酶结构域 10）。
生化／生理作用
GI254023X 是一种强效、选择性 ADAM10 金属蛋白酶抑制剂，对 α-分泌酶 ADAM10 的选择性是 ADAM17 (TACE) 的 100 倍。在使用重组 TACE 和 ADAM10 胞外域的研究中，GI254023X 的 IC50 ADAM10 为 5.3 nM，TACE 为 541 nM。
GI254023X 是一种强效选择性 ADAM10 金属蛋白酶抑制剂。
GI254023X 阻断 ADAM10（ADAM 金属肽酶域 10）的活性，并降低上皮细胞和内皮细胞中人类白细胞抗原 (HLA) 介导的细胞毒性和细胞外 E-cadherin 的裂解。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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