SML0739
TAPI-1 acetate salt
≥97% (HPLC)
同義詞:
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt
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About This Item
經驗公式（希爾表示法）:
C26H37N5O5 · xC2H4O2
CAS號碼:
分子量：:
499.60 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77
推薦產品
品質等級
化驗
≥97% (HPLC)
形狀
powder
顏色
white to beige
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1
InChI 密鑰
AWNBSWDIOCXWJW-WTOYTKOKSA-N
應用
TAPI-1 acetate salt has been used as a tumor necrosis factor(TNF)-α convertase/ADAM17/α-secretase (TACE) inhibitor.
生化／生理作用
TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host immune system after penetrating epithelial barriers such as the vaginal mucosa. In response to TSST-1, human vaginal
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(43), 15329-15339 (2011-10-28)
The capacity of adult mammals to regenerate sensory hair cells is not well defined. To explore early steps in this process, we examined reactivation of a transiently expressed developmental gene, Atoh1, in adult mouse utricles after neomycin-induced hair cell death
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Stefan Düsterhöft et al.
Cellular and molecular life sciences : CMLS, 78(11), 5015-5040 (2021-05-06)
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional
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