SML0474

(S)-度洛西汀 盐酸盐

≥98% (HPLC)

• 同義詞: (γS)-N-甲基-3-(萘-1-基氧)-3-(噻吩-2-基)丙烷-1-胺 盐酸盐, (+)-(S)-N-甲基-γ-(1-萘氧基)-2-噻吩丙胺 盐酸盐, (+)-N-甲基-3-(1-萘氧基)-3-(2-噻吩)-丙胺 盐酸盐, LY-248686 盐酸盐
• 經驗公式（希爾表示法）: C₁₈H₁₉NOS · HCl
• CAS號碼: 136434-34-9
• 分子量：: 333.88
• MDL號碼: MFCD06407958
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825429
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D +116 to +125°, c = 1 in methanol
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 5 mg/mL (clear solution, warmed)
• 儲存溫度: room temp
• SMILES 字串: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• InChI 密鑰: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• 基因資訊: human ... SLC6A2(6530) , SLC6A4(6532)

描述

一般說明

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

應用

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

生化／生理作用

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂（SNRI），在临床上被广泛用作抗抑郁药和抗焦虑药。

盐酸度洛西汀是一种双重血清素/去甲肾上腺素再摄取抑制剂（SNRI）；抗抑郁药；抗焦虑药。

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

air sensitive

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable