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Merck
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SML0400

Sigma-Aldrich

ML204

≥98% (HPLC)

同義詞:

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

經驗公式（希爾表示法）:
C15H18N2
CAS號碼:
5465-86-1
分子量：:
226.32
MDL號碼:
MFCD00817920
分類程式碼代碼:
12352200
PubChem物質ID:
329825396
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL at warmed (clear solution)

儲存溫度

2-8°C

SMILES 字串

Cc1cc(nc2ccccc12)N3CCCCC3

InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

InChI 密鑰

USYRQXDHKXGTCK-UHFFFAOYSA-N

應用

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

生化／生理作用

ML204 is a potent and selective TRPC4 channel inhibitor.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
035M4607V
054M4609V
062M4621V

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Peng Sun et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(12), 2164-2172 (2017-09-25)
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Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice
Lee SH, et al.
The Journal of Allergy and Clinical Immunology, 142(4), 1349-1352 (2018)
Stephanie D Jones et al.
Zoology (Jena, Germany), 118(6), 439-445 (2015-08-25)
The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to test this hypothesis are often ambivalent or even contradictory, and few studies have simultaneously evaluated how
Domingos M S Pereira et al.
Oxidative medicine and cellular longevity, 2018, 4904696-4904696 (2018-07-10)
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of
Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
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