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Key Documents

SML0285

Sigma-Aldrich

Pleuromutilin

≥95%

同義詞:

Drosophilin B, Mutilin 14-glycolate, NSC 121145

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About This Item

經驗公式(希爾表示法):
C22H34O5
CAS號碼:
分子量::
378.50
EC號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95%

形狀

powder

光學活性

[α]/D +30 to +40° (c=1; CH2Cl2)

顏色

white to beige

溶解度

DMSO: >10 mg/mL (warmed)

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CO

InChI

1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1

InChI 密鑰

ZRZNJUXESFHSIO-BKUNHTPHSA-N

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生化/生理作用

Pleuromutilin is a diterpene that acts against gram positive bacteria and mycoplasm. It is present in Pleurotus mutilus and Pleurotus passecherianus. Pleuromutilin exhibits its antibacterial action by interfering with the prokaryotic 70S ribosomal subunit and inactivates initiation complex. Pleuromutilin is useful in treating mycoplasma infections in animals.
Pleuromutilin is an antibiotic natural product that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase center and inhibiting peptide bond formation.

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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James E Ross et al.
Journal of clinical microbiology, 50(10), 3361-3364 (2012-07-21)
MIC and disk diffusion quality control (QC) ranges were established for two new pleuromutilin antimicrobials (BC-3205 and BC-3781) in an eight-laboratory study performed according to Clinical and Laboratory Standards Institute M23-A3 guidelines. Staphylococcus aureus ATCC 29213 and 25923, Streptococcus pneumoniae
Izabela Karpiuk et al.
Przeglad epidemiologiczny, 66(4), 567-573 (2012-01-01)
Development of new mechanisms of resistance and relatively easy and fast transferring of resistance genes between cells have resulted in emergence of large number of multi-drug resistant bacteria in recent years. Therefore, it is important to intensively search for new
Junjia Liu et al.
Chemical communications (Cambridge, England), 47(5), 1500-1502 (2010-11-17)
Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The
A dialdehyde cyclization cascade: an approach to pleuromutilin.
Matthew D Helm et al.
Angewandte Chemie (International ed. in English), 48(49), 9315-9317 (2009-11-11)
The enterococcal ABC transporter gene lsa(E) confers combined resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Sarah Wendlandt et al.
The Journal of antimicrobial chemotherapy, 68(2), 473-475 (2012-10-11)

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