SML0198

非诺多泮 甲磺酸酯

≥98% (HPLC)

• 同義詞: Fenoldopam methanesulfonate
• 經驗公式（希爾表示法）: C₁₆H₁₆ClNO₃ · CH₄O₃S
• CAS號碼: 67227-57-0
• 分子量：: 401.86
• EC號碼: 266-612-7
• MDL號碼: MFCD04112986
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825223
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to tan
• mp: 271 °C (lit.)
• 溶解度: DMSO: ≥15 mg/mL at ~60 °C
• 儲存溫度: room temp
• SMILES 字串: CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
• InChI: 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
• InChI 密鑰: CVKUMNRCIJMVAR-UHFFFAOYSA-N
• 基因資訊: human ... DRD1(1812)

描述

應用

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

生化／生理作用

Dopamine D1-receptor agonist; Antihypertensive

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.

Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H317,H319
• 防範說明: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable