推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to tan
溶解度
DMSO: ≥10 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl
InChI
1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
InChI 密鑰
LJTSJTWIMOGKRJ-UHFFFAOYSA-N
應用
Tubastatin A盐酸盐可用于HDAC6介导的细胞信号传导研究。
生化／生理作用
Tubastatin A是一种选择性很强的HDAC6抑制剂，IC50为4 nM，它对HDAC6的选择性比其他HDAC类高100至1000倍以上。
Tubastatin A能够增加线粒体的总数并恢复DRG神经元中移动线粒体的数量。它能够逆转腓骨肌萎缩症小鼠模型中外周神经元的轴突丧失。 Tubastatin A可以抑制小鼠成肌细胞中α-微管蛋白的去乙酰化。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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文章
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