SMB01055

Colladin

≥90% (LC/MS-ELSD)

• 同義詞: Coladin
• 經驗公式（希爾表示法）: C₂₆H₃₂O₅
• CAS號碼: 28691-96-5
• 分子量：: 424.53
• 分類程式碼代碼: 12352205
• NACRES: NA.25

屬性

• 生物源: plant
• 化驗: ≥90% (LC/MS-ELSD)
• 形狀: solid
• 分子量: 424.53
• 溶解度: water: slightly soluble
• 應用: metabolomics; vitamins, nutraceuticals, and natural products
• 儲存溫度: −20°C
• SMILES 字串: O1c2c(ccc(c2)OC[C@H]3[C@]4([C@@H](C([C@@H](CC4)OC(=O)C)(C)C)CCC3=C)C)C=CC1=O
• InChI: 1S/C26H32O5/c1-16-6-10-22-25(3,4)23(30-17(2)27)12-13-26(22,5)20(16)15-29-19-9-7-18-8-11-24(28)31-21(18)14-19/h7-9,11,14,20,22-23H,1,6,10,12-13,15H2,2-5H3/t20-,22-,23-,26+/m1/s1

描述

一般說明

Colladin, a sesquiterpenoid coumarin, is a natural product commonly available from Ferula Sp. (F. arrigonii, F. vesceritensis, F. campestris and F. sinaica) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including anticancer, neuroprotective, and antiglaucoma properties.

應用

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化／生理作用

According to the existing research, Coladin exhibited notable anti-cancer properties by substantially reducing cell proliferation and mitochondrial dehydrogenase activity in mouse B16F1 melanoma cells. These effects induced apoptosis through mechanisms involving decreased mitochondrial membrane potential and mitochondrial respiratory rate, underscoring its potential as a natural anti-cancer agent. Isolated from the roots of Ferulago campestris, coladin, along with other compounds such as umbelliprenin and epielmanticine, displayed inhibitory activity against Acetylcholinesterase (AChE) with an IC50 of 0.1 mM, suggesting its potential application in the treatment of neurological disorders like Alzheimer′s disease. Coladin, identified as one of the constituents in Heptaptera triquetra fruit, exhibited remarkable inhibitory activity against acetylcholinesterase (AChE), human carbonic anhydrase isoenzyme (hCA) I, and hCA II, with IC50 values of 8.25 nM, 28.90 nM, and 43.31 nM, respectively. This highlights its potential in the development of phytotherapeutics for conditions like Alzheimer′s disease (AD) and glaucoma.

特點和優勢

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

其他說明

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安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable