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Key Documents

SMB01050

Sigma-Aldrich

Licochalcone B

≥85% (LC/MS-ELSD)

同義詞:

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 3,4,4′-trihydroxy-2-methoxychalcone

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About This Item

經驗公式(希爾表示法):
C16H14O5
CAS號碼:
分子量::
286.28
MDL號碼:
分類程式碼代碼:
12352205
NACRES:
NA.25

生物源

plant

化驗

≥85% (LC/MS-ELSD)

形狀

solid

分子量

286.28

溶解度

water: slightly soluble

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

InChI

1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+

InChI 密鑰

DRDRYGIIYOPBBZ-XBXARRHUSA-N

一般說明

Licochalcone B is a prenylated flavonoid classified within the group of retrochalcones. This bioactive natural compound is commonly sourced from Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, and G. aspera) plants. Existing research indicates that this plant-derived metabolite possesses a wide array of biological activities, including antibacterial, cardioprotective, anticancer, antioxidant, antiapoptotic, neuroprotective and anti-inflammatory properties.

應用

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化/生理作用

According to the existing research, Licochalcone B exerts its effects through multiple pathways, making it a versatile candidate for various therapeutic applications. It effectively combats inflammation by inhibiting NF-κB activation induced by LPS, leading to reduced production of NO, TNFα, and MCP-1. For bladder cancer, Licochalcone B demonstrates its potential by inducing S phase arrest, modulating cell cycle-related proteins, suppressing anti-apoptotic factors, and activating caspase-3. These actions collectively limit tumor growth in vivo, suggesting its utility in both bladder cancer therapy and prevention. Furthermore, Licochalcone B showcases robust antioxidant capabilities, successfully mitigating lipid peroxidation and lowering ROS production. It also exhibits anti-inflammatory properties by decreasing the release of NO, IL-6, and PGE2 in response to LPS. Furthermore, Licochalcone B emerges as a promising candidate for Alzheimer′s disease treatment, effectively preventing Aβ42 aggregation, chelating metal ions, and providing neuroprotection.

特點和優勢

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

其他說明

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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