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![[亮氨酸15]-胃泌素 I 人类 ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/153/342/d4cb3dd7-13f1-46cf-8d1f-3907a5de7a83/640/d4cb3dd7-13f1-46cf-8d1f-3907a5de7a83.png)
化驗
≥92% (HPLC)
形狀
lyophilized
成份
Peptide Content, ≥75%
儲存條件
protect from light
儲存溫度
−20°C
Amino Acid Sequence
Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp
一般說明
Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.
應用
Gastrin I (1-14) has been used:
- as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture
- as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)
- in viable lymphocytes culture for re-stimulation assay
生化／生理作用
Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.
The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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C M Thorburn et al.
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