SBR00024

Trimethoprim Ready Made Solution

25 mg/mL in DMSO

• 同義詞: Trimethoprim Ready Made Solution
• 經驗公式（希爾表示法）: C₁₄H₁₈N₄O₃
• 分子量：: 290.32
• 分類程式碼代碼: 51285203
• NACRES: NA.76

屬性

• 生物源: synthetic
• 化驗: ≥98% (HPLC)
• 形狀: liquid
• 濃度: 25 mg/mL in DMSO
• 顏色: colorless to faint yellow
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用方式: DNA synthesis | interferes; enzyme | inhibits
• 儲存溫度: −20°C
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18
• InChI 密鑰: IEDVJHCEMCRBQM-UHFFFAOYSA-N

描述

一般說明

Trimethoprim, an aminopyrimidine antibiotic belonging to the methoxybenzenes group, exhibits activity against a broad spectrum of both gram-negative and gram-positive aerobic bacteria. As a synthetic derivative of pyrimidine, it plays a multifaceted role as an inhibitor, xenobiotic, and allergen, featuring antibacterial, diuretic, and antiprotozoal properties. Trimethoprim selectively targets dihydrofolate reductase (DHFR), diminishing the levels of tetrahydrofolate that supply one-carbon units crucial for biosynthesis processes, including nucleotides, proteins, and panthotenate, especially in prokaryotic microorganisms.

Additionally, it is frequently employed in combination with sulfamethoxazole (sc-208405) to effectively inhibit the growth of Staphylococcus aureus, functioning as a dihydrofolate reductase inhibitor. This versatile compound finds applications in metabolomics, cell biology, and biochemical research.

應用

Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.

生化／生理作用

Mode of Action: Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR.

Activity Spectrum: Effective against Gram-negative bacteria, Gram-positive bacteria, and mycobacteria

Some of the pathogens that trimethoprim can be effective against include:

• Escherichia coli (E. coli)
• Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus or MRSA)
• Streptococcus pneumoniae
• Haemophilus influenzae
• Enterococcus faecalis
• Klebsiella species
• Proteus species

特點和優勢

• High-quality antibiotic suitable for multiple research applications
• Ideal for Cell Biology, Metabolomics, and Biochemical research.

其他說明

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安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F
• 閃點（°C）: 87 °C