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重要文件

SAB4504551

Sigma-Aldrich

Anti-phospho-Synuclein-α (pTyr133) antibody produced in rabbit

affinity isolated antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 14 kDa

物種活性

mouse, human, rat

濃度

~1 mg/mL

技術

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pTyr133)

基因資訊

human ... SNCA(6622)

一般說明

The SNCA (synuclein α) gene codes for a 140-amino acid protein a-synuclein, that is mapped to human chromosome 4q21-23.

免疫原

The antiserum was produced against synthesized peptide derived from human Synuclein-alpha around the phosphorylation site of Tyr133.

Immunogen Range: 91-140

生化/生理作用

Synuclein-α is known to induce oligodendrocyte maturation. Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Mutations in the SNCA gene results in Parkinson′s disease.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy
Kiely AP, et al.
Acta Neuropathologica, 125(5), 753-769 (2013)
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update
Nuytemans K, et al.
Human Mutation, 31(7), 763-780 (2010)
?-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.
Ettle B
Acta Neuropathologica, 132(1), 59-75 (2016)

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