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Merck
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Key Documents

SAB4503194

Sigma-Aldrich

Anti-Calmodulin antibody produced in rabbit

affinity isolated antibody

同義詞:

CALM, CALM1, CALM2, CALM3, CAM

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 16 kDa

物種活性

human, rat, mouse

濃度

~1 mg/mL

技術

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CALM1(801)

一般說明

Anti-Calmodulin Antibody detects endogenous levels of total Calmodulin protein.
Calmodulin (CaM), a highly conserved Ca2+-binding protein, is mapped to human chromosome 14q32. Calmodulin is a small protein abundantly present in the brain and coded by three genes (CALM1-3).

免疫原

The antiserum was produced against synthesized peptide derived from human Calmodulin.

Immunogen Range: 46-95

應用

Anti-Calmodulin antibody has been used in western blotting.

生化/生理作用

Calmodulin (CaM) possesses Ca2+-dependent modulatory roles. It participates in cell proliferation and muscle activity. Calmodulin plays a major role in catecholaminergic polymorphic ventricular tachycardia (CPVT) and in long QT syndrome (LQTS). This protein modulates the transcriptional processes required for proper heart function.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity and Cardiac Function in Zebrafish.
Berchtold MW, et al.
The Journal of Biological Chemistry, 291(52), 26636?26646-26636?26646 (2016)
Paeoniflorin, the Main Active Ingredient of Shuyu Capsule, Inhibits Cav1. 2 and Regulates Calmodulin/Calmodulin-Dependent Protein Kinase II Signalling.
Song C, et al.
BioMed Research International, 2017 (2017)
Orthologs of seven genes (AKT1, CDC42BPB, DIO3, EIF5, JAG2, KLC, NDUFB1) from human chromosome 14q32 map to distal chicken chromosome 5.
Boyd Y, et al.
Mammalian Genome, 13(2), 120-122 (2002)
Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Rocchetti M, et al.
Cardiovascular Research, 113(5), 531-541 (2017)
Presynaptic Calmodulin targets: lessons from structural proteomics.
Lipstein N, et al.
Expert Review of Proteomics, 14(3), 223-242 (2017)

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