SAB4200466
Anti-Desmoglein 2 (DSG2) antibody, Mouse monoclonal
clone AH12.2, purified from hybridoma cell culture
同義詞:
Monoclonal Anti-ARVC10, Monoclonal Anti-ARVD10, Monoclonal Anti-CDHF5, Monoclonal Anti-CMD1BB, Monoclonal Anti-Desmoglein 2 (DSG2) antibody produced in mouse, Monoclonal Anti-HDGC, Monoclonal Anti-desmoglein 2
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推薦產品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
AH12.2, monoclonal
分子量
antigen ~150 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 2.5-5.0 μg/mL using HeLa cells
western blot: 0.5-1.0 μg/mL using HeLa total cell extracts
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DSG2(1829)
一般說明
Monoclonal Anti-Desmoglein 2 (DSG2) (mouse IgG1 isotype) is derived from the hybridoma AH12.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with lipid raft enriched preparations of human T84 intestinal epithelial cells. Desmogleins are a family of cadherin proteins. There are four distinct desmoglein genes (DSG1-DSG4), each differentially expressed depending upon the type of tissue and the state of differentiation. Desmoglein-2 (DSG2) is widely expressed in epithelial and non-epithelial tissues, such as the intestine, epidermis, testis and heart.
免疫原
derived from the hybridoma AH12.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with lipid raft enriched preparations of human T84 intestinal epithelial cells.
應用
Monoclonal Anti-Desmoglein 2 (DSG2) antibody produced in mouse has been used in immunoblotting and immunofluorescence.
生化／生理作用
Desmogleins play an important role in the formation of desmosomes, cell to-cell adhesions, often found in both simple and squamous epithelium. These adhesions are important for ensuring tissue integrity and regulation of paracellular movement of solutes and restricting access of luminal pathogens to underlying tissue compartments. Desmoglein-2 (DSG2) has been shown to regulate numerous cellular processes, including proliferation and apoptosis. Intracellular fragments of DSG2 promote apoptosis in colonic epithelial cells. Mutations in this gene is linked to arrhythmogenic right ventricular cardiomyopathy (ARVC).
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
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Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy
Pilichou K, et al.
Circulation, 113(9), 1171-1179 (2006)
Desmoglein as a target in skin disease and beyond
Amagai M, and John RS
The Journal of Investigative Dermatology, 132(3), 776-784 (2012)
Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines
Kolegraff K, et al.
Cell adhesion & migration, 5(4), 306-314 (2011)
Lisa Leon Gallegos et al.
Scientific reports, 6, 27114-27114 (2016-06-04)
Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previously identified 27 candidate cell-cell adhesion regulatory proteins (CCARPs) whose down-regulation disrupts epithelial cell-cell adhesion during collective migration. Using a protein interaction mapping strategy, we found that
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