SAB4200215

Anti-VPS4A antibody, Mouse monoclonal

clone VPS4-110, purified from hybridoma cell culture

• 同義詞: Anti-SKD1, SKD1A, SKD2, VPS4-1, Anti-Vacuolar protein sorting factor 4A, Anti-hVPS4
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified from hybridoma cell culture
• 抗體產品種類: primary antibodies
• 無性繁殖: VPS4-110, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~50 kDa
• 物種活性: mouse, canine, bovine, human, rat
• 濃度: ~1.0 mg/mL
• 技術: immunoprecipitation (IP): suitable; western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HEK-293 cells.
• 同型: IgG1
• UniProt登錄號: Q9UN37
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... VPS4A(27183) ; mouse ... Vps4a(116733) ; rat ... Vps4a(246772)

描述

一般說明

Monoclonal Anti-VPS4A (mouse IgG1 isotype) is derived from the hybridoma VPS4-110 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human VPS4A, conjugated to KLH.

Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.

應用

Monoclonal Anti-VPS4A antibody has been used in

• immunoblotting
• immunoprecipitation
• immunolabelling

生化／生理作用

Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable